Increase in cyclic AMP concentration in a cerebral giant interneuron mimics part of a memory trace for conditioned taste aversion of the pond snail

• Otsuka Emi

  Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University

• Matsunaga Miho

  Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University

• Okada Ryuichi

  Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University

• Yamagishi Miki

  Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University

• Okuta Akiko

  Cellular and Structural Physiology Institute, Nagoya University

• Lukowiak Ken

  Hotchkiss Brain Institute, University of Calgary

• Ito Etsuro

  Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University

抄録

Conditioned taste aversion (CTA) can be classically conditioned in the pond snail Lymnaea stagnalis and subsequently be consolidated into long-term memory (LTM). The neural trace that subserves CTA-LTM can be summarized as follows: A polysynaptic inhibitory postsynaptic potential recorded in the neuron 1 medial (N1M) cell in the conditioned snails as a result of activation of the cerebral giant cell (CGC) is larger and lasts longer than that in control snails. The N1M cell is ultimately activated by the CGC via the neuron 3 tonic (N3t) cell. That is, the inhibitory monosynaptic inputs from the N3t cell to the N1M cell are facilitated. The N1M and N3t cells are the members of feeding central pattern generator, whereas the CGC is a multimodal interneuron thought to play a key role in feeding behavior. Here we examined the involvement of a second messenger, cAMP, in the establishment of the memory trace. We injected cAMP into the CGC and monitored the potentials of the B3 motor neuron activated by the CGC. B3 activity is used as an index for the synaptic inputs from the N3t cell to the N1M cell. We found that the B3 potentials were transiently enlarged. Thus, when the cAMP concentration is increased in the CGC by taste aversion training, cAMP-induced changes may play a key role in the establishment of a memory trace in the N3t cell.<br>

収録刊行物

• BIOPHYSICS

  BIOPHYSICS 9 (0), 161-166, 2013

  日本生物物理学会

キーワード

• cAMP
• conditioned taste aversion
• feeding
• <i>Lymnaea</i>
• memory trace

詳細情報

• CRID: 1390001205222675072
• NII論文ID: 130003383785
• DOI: 10.2142/biophysics.9.161
• ISSN: 13492942
• Web Site: https://www.jstage.jst.go.jp/article/biophysics/9/0/9_161/_pdf
• 本文言語コード: en
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