Pegylated interferon and ribavirin combination therapy for chronic hepatitis C associated with thyroid dysfunction

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  • Okano Miki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Okuse Chiaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Yotsuyanagi Hiroshi
    Department of Internal Medicine, Infectious Diseases, Graduate School of Medicine, University of Tokyo
  • Shima Junko
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Hattori Nobuhiro
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Shigefuku Ryuta
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Noguchi Yohei
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Hatsugai Moriaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Nakahara Kazunari
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Ikeda Hiroki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Takahashi Hideaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Matsunaga Kotaro
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Matsumoto Nobuyuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Ishii Toshiya
    Division of Gastroenterology, Department of Internal Medicine, St. Marianna University School of Medicine Yokohama City Seibu Hospital
  • Sato Akira
    Division of Gastroenterology, Department of Internal Medicine, St. Marianna University School of Medicine Yokohama City Seibu Hospital
  • Fukuda Yasunobu
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki City Tama Hospital
  • Koike Kazuhiko
    Department of Internal Medicine, Gastroenterology, Graduate School of Medicine, University of Tokyo
  • Suzuki Michihiro
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki City Tama Hospital
  • Itoh Fumio
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine

Bibliographic Information

Other Title
  • 甲状腺機能異常を伴うC型慢性肝炎に対するペグインターフェロン・リバビリン併用療法
  • コウジョウセン キノウ イジョウ オ トモナウ Cガタ マンセイ カンエン ニ タイスル ペグインターフェロン ・ リバビリン ヘイヨウ リョウホウ

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Abstract

Detail of pegylated interferon and ribavirin combination therapy (combination therapy) for 12 patients with chronic hepatitis C associated with thyroid dysfunction (TD) was investigated. All patients were diagnosed as having TD at the start of combination therapy according to measurements of free thyroxine, free tri iodothyronine, and thyroid stimulating hormone. The 12 patients were diagnosed as follows; 4 as subclinical-hypothyroidism, 4 as overt-hypothyroidism, and 4 as subclinical-hyperthyroidism. Two anti-thyroid peroxidase antibodies (TPO Ab)-positive patients with overt-hypothyroidism undertook thyroid hormone replacement after the start of combination therapy, of whom subsequent thyroid function stabilized and combination therapy could be continued. On the other hand, thyroid function in 5 TPO Ab-negative patients was normalized after the start of combination therapy. In this study, no patient was discontinued the combination therapy for the reason of exacerbation of TD.

Journal

  • Kanzo

    Kanzo 54 (11), 731-740, 2013

    The Japan Society of Hepatology

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