Synthesis of 1-(4-Aminobutyl)-2-iminoimidazolidin-4-one Aimed at Preparation of a Creatinine-Specific Antibody
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- Moriya Shun-suke
- Translational Medical Research Center, Tokyo Metropolitan Institute of Medical Science
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- Terayama Naoki
- Department of Applied Chemistry, Kogakuin University
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- Hiramatsu Kyoko
- Translational Medical Research Center, Tokyo Metropolitan Institute of Medical Science
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- Kawakita Masao
- Translational Medical Research Center, Tokyo Metropolitan Institute of Medical Science
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- Kiryu Tatsuya
- Department of Applied Chemistry, Kogakuin University
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- Kawanishi Takato
- Department of Applied Chemistry, Kogakuin University
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- Yasui Eiko
- Department of Applied Chemistry, Kogakuin University
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- Nagumo Shinji
- Department of Applied Chemistry, Kogakuin University
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Abstract
For the purpose of obtaining a creatinine-specific antibody, a creatinine derivative with 4-aminobutyl, which was served as a linker for preparing the creatinine–bovine serum albumin (BSA) conjugate, was synthesized from 4-benzylaminobutan-1-ol in 8 steps. Production of anti-creatinine antibodies was observed in two rabbits using the creatinine–BSA conjugate, although their titer was rather low.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 62 (4), 350-353, 2014
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679153262592
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- NII Article ID
- 130003390789
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- NII Book ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC2cvisVejsA%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 025371036
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- PubMed
- 24499923
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed