Xanthocidin Derivatives as Topoisomerase IIα Enzymatic Inhibitors
-
- Takeda Shuso
- Department of Molecular Biology, Daiichi University of Pharmacy
-
- Yaji Kentaro
- Interdisciplinary Graduate School of Engineering Sciences, Kyushu University
-
- Matsumoto Kenji
- Institute for Materials Chemistry and Engineering, Kyushu University
-
- Amamoto Toshiaki
- NEUES Corporation
-
- Shindo Mitsuru
- Institute for Materials Chemistry and Engineering, Kyushu University
-
- Aramaki Hironori
- Department of Molecular Biology, Daiichi University of Pharmacy
この論文をさがす
抄録
Few studies have examined xanthocidin, a biotic isolated from Streptomyces xanthocidicus in 1966, because its supply is limited. Based on its chemical structure, xanthocidin has the potential to become a lead compound in the production of agrochemicals and anti-cancer drugs; however, it is unstable under both basic and acidic conditions. We recently established the total synthesis of xanthocidin using the FeCl3-mediated Nazarov reaction, and obtained two stable derivatives (#1 and #2). The results of the present study demonstrated that these derivatives exhibited the inhibitory activity of topoisomerase IIα, known as a molecular target for cancer chemotherapy, and this was attributed to the respective exo-methylene ketone group without DNA intercalation. The results obtained also suggest that these derivatives may have value as lead compounds in the synthesis of topoisomerase IIα inhibitors.
収録刊行物
-
- Biological & Pharmaceutical Bulletin
-
Biological & Pharmaceutical Bulletin 37 (2), 331-334, 2014
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204633309440
-
- NII論文ID
- 130003390933
-
- NII書誌ID
- AA10885497
-
- COI
- 1:STN:280:DC%2BC2cvhvVCqsQ%3D%3D
-
- ISSN
- 13475215
- 09186158
-
- NDL書誌ID
- 025172991
-
- PubMed
- 24492731
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可