長鎖脂肪酸受容体G protein-coupled receptor 40 (GPR40) を介した docosahexaenoic acid (DHA) の抗侵害作用機構  [in Japanese] Antinociceptive Effect of Docosahexaenoic Acid (DHA) through Long Fatty Acid Receptor G Protein-coupled Receptor 40 (GPR40)  [in Japanese]

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Author(s)

    • 中本 賀寿夫 Nakamoto Kazuo
    • 神戸学院大学薬学部臨床薬学研究室 Department of Clinical Pharmacy, Kobe Gakuin University; School of Pharmaceutical Sciences
    • 西中 崇 Nishinaka Takashi
    • 神戸学院大学薬学部臨床薬学研究室 Department of Clinical Pharmacy, Kobe Gakuin University; School of Pharmaceutical Sciences
    • 里 尚也 [他] Sato Naoya
    • 神戸学院大学薬学部臨床薬学研究室 Department of Clinical Pharmacy, Kobe Gakuin University; School of Pharmaceutical Sciences
    • 万倉 三正 Mankura Mitsumasa
    • 神戸学院大学薬学部臨床薬学研究室 Department of Clinical Pharmacy, Kobe Gakuin University; School of Pharmaceutical Sciences
    • 小山 豊 Koyama Yutaka
    • 神戸学院大学薬学部臨床薬学研究室 Department of Clinical Pharmacy, Kobe Gakuin University; School of Pharmaceutical Sciences
    • 徳山 尚吾 Tokuyama Shogo
    • 神戸学院大学薬学部臨床薬学研究室 Department of Clinical Pharmacy, Kobe Gakuin University; School of Pharmaceutical Sciences

Abstract

  Fatty acids, one class of essential nutrients for humans, are an important source of energy and an essential component of cell membranes. They also function as signal transduction molecules in a variety of biological phenomena. The important functional role of fatty acids in both onset and suppression of pain has become increasingly apparent in recent years. Recently, we have also demonstrated that the release of an endogenous opioid peptide, β-endorphin, plays an important role in the induction of docosahexaenoic acid (DHA)-induced antinociception. It is well known that fatty acids affect intracellular and intercellular signaling as well as the membrane fluidity of neurons. In addition to intracellular actions, unbound free fatty acids (FFAs) can also carry out extracellular signaling by stimulating the G protein-coupled receptor (GPCR). Among these receptors, G protein-coupled receptor 40 (GPR40) has been reported to be activated by long-chain fatty acids such as DHA, eicosapentaenoic acid (EPA) and arachidonic acid. In the peripheral area, GPR40 is preferentially expressed in pancreatic β-cells and is known to relate to the secretion of hormone and peptides. On the other hand, even though this receptor is widely distributed in the central nervous system, reports studying the role and functions of GPR40 in the brain have not been found. In this review, we summarize the findings of our recent study about the long-chain fatty acid receptor GPR40 as a novel pain regulatory system.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 134(3), 397-403, 2014

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130003391182
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • ISSN
    0031-6903
  • NDL Article ID
    025300767
  • NDL Call No.
    Z19-411
  • Data Source
    NDL  J-STAGE 
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