長鎖脂肪酸受容体G protein-coupled receptor 40 (GPR40) を介した docosahexaenoic acid (DHA) の抗侵害作用機構

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  • Antinociceptive Effect of Docosahexaenoic Acid (DHA) through Long Fatty Acid Receptor G Protein-coupled Receptor 40 (GPR40)
  • Symposium Review 長鎖脂肪酸受容体G protein-coupled receptor 40 (GPR40)を介したdocosahexaenoic acid (DHA)の抗侵害作用機構
  • Symposium Review チョウサ シボウサン ジュヨウタイ G protein-coupled receptor 40 (GPR40)オ カイシタ docosahexaenoic acid (DHA)ノ コウシンガイ サヨウ キコウ

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  Fatty acids, one class of essential nutrients for humans, are an important source of energy and an essential component of cell membranes. They also function as signal transduction molecules in a variety of biological phenomena. The important functional role of fatty acids in both onset and suppression of pain has become increasingly apparent in recent years. Recently, we have also demonstrated that the release of an endogenous opioid peptide, β-endorphin, plays an important role in the induction of docosahexaenoic acid (DHA)-induced antinociception. It is well known that fatty acids affect intracellular and intercellular signaling as well as the membrane fluidity of neurons. In addition to intracellular actions, unbound free fatty acids (FFAs) can also carry out extracellular signaling by stimulating the G protein-coupled receptor (GPCR). Among these receptors, G protein-coupled receptor 40 (GPR40) has been reported to be activated by long-chain fatty acids such as DHA, eicosapentaenoic acid (EPA) and arachidonic acid. In the peripheral area, GPR40 is preferentially expressed in pancreatic β-cells and is known to relate to the secretion of hormone and peptides. On the other hand, even though this receptor is widely distributed in the central nervous system, reports studying the role and functions of GPR40 in the brain have not been found. In this review, we summarize the findings of our recent study about the long-chain fatty acid receptor GPR40 as a novel pain regulatory system.<br>

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  • 薬学雑誌

    薬学雑誌 134 (3), 397-403, 2014-03-01

    公益社団法人 日本薬学会

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