Pharmacology : N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs
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- NAGASAWA Miho
- Department of Animal Science and Biotechnology, Azabu University, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan
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- SHIMOZAWA Aki
- Department of Animal Science and Biotechnology, Azabu University, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan
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- MOGI Kazutaka
- Department of Animal Science and Biotechnology, Azabu University, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan
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- KIKUSUI Takefumi
- Department of Animal Science and Biotechnology, Azabu University, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan
書誌事項
- タイトル別名
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- N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs
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抄録
This study aimed to investigate the therapeutic effects of N-acetyl-D-mannosamine (ManNAc) on age-related cognitive dysfunction in dogs. ManNAc was administered to 5 dogs with low cognitive levels for 2 months, and the cognitive ability and active-resting cycle were periodically assessed for improvement. ManNAc treatment significantly reduced the number of error trials in the place-learning test, especially in the first month of administration. Three ManNAc-treated dogs also showed improvement in the active-resting cycle. In conclusion, ManNAc treatment appears to alleviate age-related cognitive dysfunction.
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 76 (5), 757-761, 2014
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206428953984
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- NII論文ID
- 130003391262
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- NII書誌ID
- AA10796138
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- COI
- 1:STN:280:DC%2BC2czlslOhtg%3D%3D
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 025556670
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- PubMed
- 24430654
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可