Ectopic Tissue Consisting of a Mixture of Glandular Gastric, Intestinal, and Exocrine Pancreatic Tissue in the Forestomach of a Rat

• Kato Yuki

  Developmental Research Laboratories, Shionogi & Co., Ltd. Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University

• Hirata Akihiro

  Division of Animal Experiment, Life Science Research Center, Gifu University

• Kashiwagi-Yamamoto Emi

  Developmental Research Laboratories, Shionogi & Co., Ltd. Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University

• Masuno Koichi

  Developmental Research Laboratories, Shionogi & Co., Ltd.

• Fujisawa Kae

  Developmental Research Laboratories, Shionogi & Co., Ltd.

• Matsushima Shuuichi

  Developmental Research Laboratories, Shionogi & Co., Ltd.

• Takasu Nobuo

  Developmental Research Laboratories, Shionogi & Co., Ltd.

Abstract

The development of ectopic gastric, intestinal, or pancreatic tissue in the gastrointestinal tract is extremely rare in rats, although it is fairly common in humans. In this report, we describe an unusual case in which a mixture of different types of ectopic tissue was found in the forestomach of a rat. A solitary white nodular/polypoid structure, which measured 5 mm in size, was detected on the luminal surface of the greater curvature of the forestomach in an 8-week-old female Crl:CD(SD) rat. A histological examination revealed that the lesion contained ectopic glandular gastric tissue, including gastric surface mucous cells, parietal cells, and pyloric gland cells, which was confirmed by immunohistochemistry. Moreover, the lesion also contained villin-positive columnar intestinal absorptive cells and chymotrypsin-positive pancreatic exocrine tissue. To the best of our knowledge, this is the first study to detect a mixture of ectopic glandular gastric, intestinal, and exocrine pancreatic tissue in a rat.

Journal

• Journal of Toxicologic Pathology

  Journal of Toxicologic Pathology 27 (1), 87-90, 2014

  JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY

Keywords

• choristoma
• ectopic
• forestomach
• heterotopic
• rat

Details

• CRID: 1390001204414109952
• NII Article ID: 130003391340
• NII Book ID: AN10232280
• DOI: 10.1293/tox.2013-0058
• COI: 1:STN:280:DC%2BC2cnpsFagsA%3D%3D
• ISSN: 1881915X
• ISSN: 09149198
• NDL BIB ID: 025510391
• PubMed: 24791072
• Web Site: http://id.ndl.go.jp/bib/025510391
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025510391
• Web Site: https://www.jstage.jst.go.jp/article/tox/27/1/27_2013-0058/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015032950
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed