Critical Review : The Roles of Diacylglycerol Kinases in the Central Nervous System : Review of Genetic Studies in Mice
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- Ishisaka Mitsue
- Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan
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- Hara Hideaki
- Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan
書誌事項
- タイトル別名
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- The Roles of Diacylglycerol Kinases in the Central Nervous System: Review of Genetic Studies in Mice
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抄録
Diacylglycerol kinase (DGK) is an enzyme that converts diacylglycerol to phosphatidic acid. To date, 10 isoforms of DGKs (α, β, γ, δ, ε, ζ, η, θ, ι, and κ) have been identified in mammals, and these DGKs show characteristic expression patterns and roles. The expression levels of DGKs are comparatively higher in the central nervous system than in other organs and may play several important roles in regulating higher brain functions. Currently, many studies have been performed to reveal the roles of DGKs by knocking down or overexpression of DGKs in vitro. Additionally, knockout or overexpression mice of several DGKs have been generated, and phenotypes of these mice have been studied. In this review, we discuss the roles of DGKs in the central nervous system based on recent findings in genetic models.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 124 (3), 336-343, 2014
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205180868736
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- NII論文ID
- 130003391496
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- NII書誌ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC2cXlsF2ms70%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 025362414
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- PubMed
- 24599142
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可