Pharmacological Characterization of Standard Analgesics on Oxaliplatin-Induced Acute Cold Hypersensitivity in Mice
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- Zhao Meng
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
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- Nakamura Saki
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
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- Miyake Takahito
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
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- So Kanako
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
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- Shirakawa Hisashi
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
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- Tokuyama Shogo
- Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Japan Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences, Japan
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- Narita Minoru
- Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences, Japan Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan
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- Nakagawa Takayuki
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences, Japan Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Japan
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- Kaneko Shuji
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
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抄録
Oxaliplatin, a platinum-based chemotherapeutic agent, causes an acute peripheral neuropathy triggered by cold in almost all patients during or within hours after its infusion. We recently reported that a single administration of oxaliplatin induced cold hypersensitivity 2 h after the administration in mice. In this study, we examined whether standard analgesics relieve the oxaliplatin-induced acute cold hypersensitivity. Gabapentin, tramadol, mexiletine, and calcium gluconate significantly inhibited and morphine and milnacipran decreased the acute cold hypersensitivity, while diclofenac and amitriptyline had no effects. These results suggest that gabapentin, tramadol, mexiletine, and calcium gluconate are effective against oxaliplatin-induced acute peripheral neuropathy.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 124 (4), 514-517, 2014
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680155139328
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- NII論文ID
- 130003391509
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- NII書誌ID
- AA11806667
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- COI
- 1:STN:280:DC%2BC2crnvVWmtA%3D%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 025428622
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- PubMed
- 24671055
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可