Pharmacological Characterization of Standard Analgesics on Oxaliplatin-Induced Acute Cold Hypersensitivity in Mice

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  • Zhao Meng
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
  • Nakamura Saki
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
  • Miyake Takahito
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
  • So Kanako
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
  • Shirakawa Hisashi
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
  • Tokuyama Shogo
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Japan Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences, Japan
  • Narita Minoru
    Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences, Japan Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan
  • Nakagawa Takayuki
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences, Japan Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Japan
  • Kaneko Shuji
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan

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Abstract

Oxaliplatin, a platinum-based chemotherapeutic agent, causes an acute peripheral neuropathy triggered by cold in almost all patients during or within hours after its infusion. We recently reported that a single administration of oxaliplatin induced cold hypersensitivity 2 h after the administration in mice. In this study, we examined whether standard analgesics relieve the oxaliplatin-induced acute cold hypersensitivity. Gabapentin, tramadol, mexiletine, and calcium gluconate significantly inhibited and morphine and milnacipran decreased the acute cold hypersensitivity, while diclofenac and amitriptyline had no effects. These results suggest that gabapentin, tramadol, mexiletine, and calcium gluconate are effective against oxaliplatin-induced acute peripheral neuropathy.

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