Ribosomal RNA gene repeats, their stability and cellular senescence

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Author(s)

Abstract

The ribosomal RNA gene (rDNA) repeats form a historically well-researched region in the chromosome. Their highly repetitive structure can be identified easily which has enabled studies on DNA replication, recombination, and transcription. The region is one of the most unstable regions in the genome because of deleterious recombination among the repeats. The ribosomal RNA gene repeats use a unique gene amplification system to restore the copy number after this has been reduced due to recombination. It has been shown that unstable features in the genome can accelerate cellular senescence that restricts the lifespan of a cell. Here, I will introduce a study by our group that shows how the stability of rDNA is maintained and affects lifespan. I propose that the ribosomal RNA gene repeats constitute a center from which the stability of the whole genome is regulated and the lifespan of the cell is controlled.

Journal

  • Proceedings of the Japan Academy, Series B

    Proceedings of the Japan Academy, Series B 90(4), 119-129, 2014

    The Japan Academy

Codes

  • NII Article ID (NAID)
    130003392358
  • NII NACSIS-CAT ID (NCID)
    AA00785485
  • Text Lang
    ENG
  • ISSN
    0386-2208
  • NDL Article ID
    025419869
  • NDL Call No.
    Z53-T495
  • Data Source
    NDL  J-STAGE 
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