Effect of Statin on the 5 Years Clinical Outcomes in Dialysis Patients Treated with Sirolimus-eluting Stent
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- Kagawa Yuzo
- Division of Cardiology, Tsuchiya General Hospital, Japan
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- Toyofuku Mamoru
- Division of Cardiology, Tsuchiya General Hospital, Japan
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- Masaoka Yoshiko
- Division of Cardiology, Tsuchiya General Hospital, Japan
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- Muraoka Yuji
- Division of Cardiology, Tsuchiya General Hospital, Japan
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- Okimoto Tomokazu
- Division of Cardiology, Tsuchiya General Hospital, Japan
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- Otsuka Masaya
- Division of Cardiology, Tsuchiya General Hospital, Japan
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- Tamekiyo Hiromichi
- Division of Cardiology, Tsuchiya General Hospital, Japan
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- Mito Shinji
- Division of Cardiology, Tsuchiya General Hospital, Japan
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- Kawase Tomoharu
- Division of Cardiology, Tsuchiya General Hospital, Japan
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- Yamane Kenichi
- Division of Cardiology, Tsuchiya General Hospital, Japan
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- Amioka Michitaka
- Division of Cardiology, Tsuchiya General Hospital, Japan
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- Shiode Nobuo
- Division of Cardiology, Tsuchiya General Hospital, Japan
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- Hayashi Yasuhiko
- Division of Cardiology, Tsuchiya General Hospital, Japan
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抄録
Objective The optimal medication therapies are recommended in patients with coronary artery disease even after the coronary revascularization. However, the information of optimal medical therapy in dialysis population is scant. We assessed the efficacy of statin on the clinical outcomes after Sirolimus-eluting stent (SES) implantation in patients with and without dialysis.<br> Methods and Results We analyzed date from 843 consecutive patients who successfully treated with SES in our institution between August 2004 and November 2006. Among patients, 96 patients (11.4%) were undergoing dialysis. In non-dialysis patients, 405 patients (54%) were treated with statin at hospital discharge. In dialysis patients, only 16 patients (17%) were treated with statin. In non-dialysis patients, mortality rate was significantly lower in patients treated with statin than those without statin (4.4% vs. 13.9%, p<0.0001). While in dialysis patients, mortality rate was similar between patients treated with and without statin (56.3% vs. 57.6%, p=0.86). After adjusting for confounders, the hazard ratios for mortality were 0.39 (95% confidence interval (CI), 0.14-0.99; p=0.047) in non-dialysis patients and 1.79 (95% CI, 0.39-7.86; 0.45) for dialysis patients. The interaction probability between statin use and dialysis for mortality was 0.016.<br> Conclusion The use of statin may have beneficial effect on reducing mortality rate in patients after SES implantation in non-dialysis patients. However, such favorable effect was not observed in dialysis population.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 53 (2), 89-94, 2014
一般社団法人 日本内科学会