Comprehensive Analysis of Systemically Disseminated ST8/non-USA300 type Community-acquired Methicillin-resistant <i>Staphylococcus aureus</i> Infection

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Author(s)

    • Hagiya Hideharu
    • Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan|Emergency Unit and Critical Care Center, Tsuyama Central Hospital, Japan
    • Hisatsune Junzo
    • Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Japan|Department of Bacteriology, Hiroshima University Graduate School of Biochemical and Health Sciences, Japan
    • Kojima Taro
    • Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Japan|Department of Bacteriology, Hiroshima University Graduate School of Biochemical and Health Sciences, Japan
    • Shiota Sumiko
    • Department of Pathogenic Microbiology, School of Pharmacy, Shujitsu University, Japan
    • Naito Hiromichi
    • Emergency Unit and Critical Care Center, Tsuyama Central Hospital, Japan
    • Hagioka Shingo
    • Emergency Unit and Critical Care Center, Tsuyama Central Hospital, Japan
    • Morimoto Naoki
    • Emergency Unit and Critical Care Center, Tsuyama Central Hospital, Japan
    • Otsuka Fumio
    • Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    • Sugai Motoyuki
    • Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Japan|Department of Bacteriology, Hiroshima University Graduate School of Biochemical and Health Sciences, Japan

Abstract

Community-acquired methicillin-resistant <i>Staphylococcus aureus</i> (CA-MRSA) is genetically heterogeneous and various genotypes are spreading worldwide. We herein report a case of systematically disseminated Japan-intrinsic CA-MRSA infection that was successfully treated. A genetically identical single strain was isolated from a total of 11 different parts of the patient's body, and the pathogen was found to be multilocus sequence type 8, staphylococcal cassette chromosome <i>mec</i> IV, coagulase type III and negative for both Panton-Valentine leukocidin and arginine catabolic mobile element. The epidemiology and pathogenicity of the Japan-intrinsic CA-MRSA strain remain unknown, and further investigation of this life-threatening organism is warranted.<br>

Journal

  • Internal Medicine

    Internal Medicine 53(8), 907-912, 2014

    The Japanese Society of Internal Medicine

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