Water-Soluble Vitamin Deficiencies in Complicated Peptic Ulcer Patients Soon after Ulcer Onset in Japan
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- MIYAKE Kazumasa
- Department of Gastroenterology, Nippon Medical School
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- AKIMOTO Teppei
- Department of Gastroenterology, Nippon Medical School
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- KUSAKABE Makoto
- Department of Gastroenterology, Nippon Medical School
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- SATO Wataru
- Department of Gastroenterology, Nippon Medical School
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- YAMADA Akiyoshi
- Department of Gastroenterology, Nippon Medical School
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- YAMAWAKI Hiroshi
- Department of Gastroenterology, Nippon Medical School
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- KODAKA Yasuhiro
- Department of Gastroenterology, Nippon Medical School
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- SHINPUKU Mayumi
- Department of Gastroenterology, Nippon Medical School
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- NAGOYA Hiroyuki
- Department of Gastroenterology, Nippon Medical School
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- SÒ Tomotaka
- Department of Gastroenterology, Nippon Medical School
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- UEKI Nobue
- Department of Gastroenterology, Nippon Medical School
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- KUSUNOKI Masafumi
- Department of Gastroenterology, Nippon Medical School
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- KAWAGOE Tetsuro
- Department of Gastroenterology, Nippon Medical School
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- FUTAGAMI Seiji
- Department of Gastroenterology, Nippon Medical School
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- TSUKUI Taku
- Department of Gastroenterology, Nippon Medical School
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- SAKAMOTO Choitsu
- Department of Gastroenterology, Nippon Medical School
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Abstract
We investigated over time whether contemporary Japanese patients with complicated peptic ulcers have any water-soluble vitamin deficiencies soon after the onset of the complicated peptic ulcers. In this prospective cohort study, fasting serum levels of water-soluble vitamins (vitamins B1, B2, B6, B12, C, and folic acid) and homocysteine were measured at 3 time points (at admission, hospital discharge, and 3 mo after hospital discharge). Among the 20 patients who were enrolled in the study, 10 consecutive patients who completed measurements at all 3 time points were analyzed. The proportion of patients in whom any of the serum water-soluble vitamins that we examined were deficient was as high as 80% at admission, and remained at 70% at discharge. The proportion of patients with vitamin B6 deficiency was significantly higher at admission and discharge (50% and 60%, respectively, p<0.05) than at 3 mo after discharge (10%). In conclusion, most patients with complicated peptic ulcers may have a deficiency of one or more water-soluble vitamins in the early phase of the disease after the onset of ulcer complications, even in a contemporary Japanese population.
Journal
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 59 (6), 503-508, 2013
Center for Academic Publications Japan
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Details 詳細情報について
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- CRID
- 1390001206324010240
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- NII Article ID
- 130003393746
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- NII Book ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BC2cXktlyhsQ%3D%3D
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- ISSN
- 18817742
- 03014800
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- NDL BIB ID
- 025136062
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- PubMed
- 24477246
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed