Stress-induced Biomarkers in Liver with Non-alcohol Fatty Liver Diseases and Non-alcohol Steatohepatitis

• Ono Hiromi

  Laboratory of Clinical Nutrition and Medicine, Kagawa Nutrition University

• Tanaka Akira

  Laboratory of Clinical Nutrition and Medicine, Kagawa Nutrition University Nutrition Clinic, Kagawa Nutrition University

• Nakazato Kyoumi

  Gunma University Graduate School of Health Sciences

• Hasegawa Yutaka

  Educational Center for Clinical Pharmacy, Kobe Pharmaceutical University

• Kim Ke Ih

  Department of Gastroenterology, Kobe Asahi Hospital

• Kim Soo Ryang

  Department of Gastroenterology, Kobe Asahi Hospital

• Nakajima Katsuyuki

  Nutrition Clinic, Kagawa Nutrition University Gunma University Graduate School of Health Sciences

• Nagamine Takeaki

  Gunma University Graduate School of Health Sciences

抄録

Background & Aims : A comparative study between plasma diagnostic markers and oxidative stress-induced biomarkers localized differently in the liver has not been reported in non-alcohol fatty liver (NAFLD) and non-alcoholic steatohepatitis (NASH). Methods : Pathological observations by Hematoxylin and Eosin (HE) staining and immunostaining by specific antibodies against metallothionein (MT)-1/2 and -3, heme oxygenase -1(HO-1), adiponectin using biopsy samples and plasma diagnostic makers were determined in 37 cases. Results : The MT-1/2, HO-1 and adiponectin levels were all significantly reduced in the liver with NASH compared with NAFLD and control. MT-1/2 was most strongly stained in hepatocytes in the normal and NAFLD liver, while it was significantly reduced in NASH. Adiponectin was stained significantly less at blood vessels in NASH compared with NAFLD and controls. HO-1 was also stained significantly less in the Kupffer cells in NASH compared with NAFLD and controls. MT-3 was stained similarly among the three groups at blood vessel cells. Those biomarkers trended negatively with plasma liver injury biomarkers. Conclusions : The significantly reduced expression of oxidative stress-induced biomarkers in NASH may be associated with the degree of pathological damage. In particular, MT-1/2 appears to exert an important effect in hepatocytes against stress-induced damage in NASH.

収録刊行物

• 北関東医学

  北関東医学 64 (1), 13-22, 2014

  北関東医学会

キーワード

• adiponectin
• heme oxygenase -1(HO-1)
• metallothionein (MT)
• NAFLD (non-alcohol fatty liver)
• NASH (non-alcoholic steatohepatitis)

詳細情報

• CRID: 1390001206343139456
• NII論文ID: 130003393784
• NII書誌ID: AN10585677
• DOI: 10.2974/kmj.64.13
• ISSN: 18811191
• ISSN: 13432826
• HANDLE: 10087/8128
• NDL書誌ID: 025305773
• Web Site: https://gunma-u.repo.nii.ac.jp/records/7979
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025305773
• Web Site: https://search.jamas.or.jp/link/ui/2014376402
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可