Hepatopulmonary syndrome in Japanese liver cirrhosis patients

• Okada Hayami

  Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Hospital Post Graduate Clinical Education Center

• Takaki Akinobu

  Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Yagi Takahito

  Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Yasunaka Tetsuya

  Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Gotoda Tatsuhiro

  Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Oe Hiroki

  Department of Cardiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Nakamura Kazufumi

  Department of Cardiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Sato Shuichi

  Department of Gastroenterology and Hepatology, Shimane University, Faculty of Medicine

• Sadamori Hiroshi

  Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Shinoura Susumu

  Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Umeda Yuzo

  Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Yoshida Ryuichi

  Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Utsumi Masashi

  Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Nobuoka Daisuke

  Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Yasuda Yuko

  Okayama University Hospital Transplantation Coordinator

• Ikeda Fusao

  Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Miyake Yasuhiro

  Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Ito Hiroshi

  Department of Cardiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Fujiwara Toshiyoshi

  Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Yamamoto Kazuhide

  Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Bibliographic Information

Other Title

• 日本人肝硬変患者における肝肺症候群―移植前血液ガススクリーニングの結果より―
• ニホンジン カンコウヘン カンジャ ニ オケル カン ハイ ショウコウグン : イショク ゼン ケツエキ ガススクリーニング ノ ケッカ ヨリ

Abstract

Hepatopulmonary syndrome is characterized by hypoxemia induced by intrapulmonary vascular dilatations associated with hepatic diseases. We evaluated the frequency and case presentations revealed by general screening before liver transplantation. Sixty-one patients underwent arterial blood gas analysis in both upright and supine positions. Of these, 27 patients (44%) showed PaO₂ <80 mmHg and AaDO₂ ≥15 mmHg, reflecting intrapulmonary shunting. Four patients exhibited PaO₂ <70 mmHg and orthodeoxia, defined as a fall in PaO₂ ≥5%or 4 mmHg in an upright position. Finally, two patients showed hepatopulmonary syndrome, with positive findings on perfusion lung scanning. Both patients with hepatopulmonary syndrome had liver cirrhosis type C with habitual alcohol drinking and smoking. Potential pulmonary shunt patients with PaO₂ <80 mmHg and AaDO₂ ≥15 mmHg exhibited higher model for end-stage liver disease scores. Care should be taken regarding hepatopulmonary syndrome during liver cirrhosis management in Japanese patients.

Journal

• Kanzo

  Kanzo 55 (3), 143-154, 2014

  The Japan Society of Hepatology

Keywords

• hepatopulmonary syndrome
• blood gas analysis
• liver cirrhosis
• liver transplantation
• hypoxemia

Details

• CRID: 1390001204794514304
• NII Article ID: 130003393968
• NII Book ID: AN00047770
• DOI: 10.2957/kanzo.55.143
• ISSN: 18813593
• ISSN: 04514203
• NDL BIB ID: 025359514
• Web Site: http://id.ndl.go.jp/bib/025359514
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025359514
• Web Site: https://www.jstage.jst.go.jp/article/kanzo/55/3/55_143/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014206999
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed