Inorganic polyphosphate adsorbed onto hydroxyapatite for guided bone regeneration: An animal study

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Author(s)

    • DOI Kazuya
    • Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences
    • KUBO Takayasu
    • Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences
    • TAKESHITA Ryou
    • Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences
    • KAJIHARA Shiho
    • Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences
    • AKAGAWA Yasumasa
    • Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences

Abstract

Inorganic polyphosphate (poly(P)) is recognized as a therapeutic agent that promotes fibroblast growth factor and enhances osteogenic differentiation, and <i>in vivo</i>, when adsorbed onto interconnected porous calcium hydroxyapatite (IP-CHA) enhances bone regeneration. The present study focused on the effect of poly(P) adsorbed onto IP-CHA granules (Poly(P)/IP-CHA) in guided bone regeneration (GBR). Dental implants were placed into the edentulous mandibular areas of five Beagle-Labrador hybrid dogs with screw expose on the buccal side, and then bone defects were filled Poly(P)/IP-CHA (test) or IP-CHA (control). After 12 weeks, histological evaluation and histomorphometrical analysis were performed. Newly-bone formation around exposed implant screw was clearly detected in the test-group. The ratio for regenerated bone height in the test group <i>versus</i> the control-group was 85.6±20.2 and 62.6±23.8, respectively, with no significant difference, while, that for bone implant contact was significantly higher (67.9±11.8 and 48.8±14.1, respectively). These findings indicate that Poly(P)/IP-CHA enhances bone regeneration in GBR.

Journal

  • Dental Materials Journal

    Dental Materials Journal 33(2), 179-186, 2014

    The Japanese Society for Dental Materials and Devices

Codes

  • NII Article ID (NAID)
    130003394967
  • Text Lang
    ENG
  • ISSN
    0287-4547
  • Data Source
    J-STAGE 
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