Antibacterial and Antifungal Activities of Tryptanthrin Derivatives

• Kawakami Jun

  Graduate School of Science and Technology, Hirosaki University

• Matsushima Noriyuki

  Graduate School of Science and Technology, Hirosaki University

• Ogawa Yuta

  Graduate School of Science and Technology, Hirosaki University

• Kakinami Hiroko

  Graduate School of Science and Technology, Hirosaki University

• Nakane Akio

  Graduate School of Medicine, Hirosaki University

• Kitahara Haruo

  Department of Chemistry, Faculty of Education, Hirosaki University

• Nagaki Masahiko

  Graduate School of Science and Technology, Hirosaki University

• Ito Shunji

  Graduate School of Science and Technology, Hirosaki University

抄録

Tryptanthrin (T) and 13 of its derivatives (T2NH₂, T2Cl, T2Br, T2NO₂, T8OMe, T8Me, T8F, T8Br, T8NO₂, T2NH₂8OMe, T2NH₂8NO₂, T2Br8Br, and T2NO₂8NO₂) were synthesized, and their antimicrobial activities against a gram-positive bacterium (methicillin-resistant Staphylococcus aureus, MRSA) and a fungus (Malassezia furfur) were investigated. The antibacterial and antifungal activities were influenced by the substituents on tryptanthrin, with halogen-substituted tryptanthrin derivatives (T2Cl, T2Br, T8F, T8Br, and T2Br8Br) showing the highest potency against MRSA and M. furfur.

収録刊行物

• Transactions of the Materials Research Society of Japan

  Transactions of the Materials Research Society of Japan 36 (4), 603-606, 2011

  一般社団法人 日本MRS

キーワード

• Antibacterial activity
• Tryptanthrin
• MRSA
• Malassezia furfur

詳細情報

• CRID: 1390282680489102976
• NII論文ID: 130003399030
• DOI: 10.14723/tmrsj.36.603
• COI: 1:CAS:528:DC%2BC38XivVensbg%3D
• ISSN: 21881650
• ISSN: 13823469
• Web Site: https://www.jstage.jst.go.jp/article/tmrsj/36/4/36_603/_pdf
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可