Changes in <i>Streptococcus pneumoniae</i> Serotypes in the Nasopharynx of Japanese Children after Inoculation with a Heptavalent Pneumococcal Conjugate Vaccine

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Author(s)

    • Ueno Masahiro Ueno Masahiro
    • Department of Pediatrics, Hasuda Issinkai Hospital|Department of Environmental and Occupational Health, School of Medicine, Toho University
    • Wada Akihito
    • Department of Bacteriology I, National Institute of Infectious Diseases|Yonaguni Medical Clinic
    • Sugita Minoru
    • Department of Environmental and Occupational Health, School of Medicine, Toho University
    • Tanaka Taichiro
    • Department of Environmental and Occupational Health, School of Medicine, Toho University
    • Nishiwaki Yuji
    • Department of Environmental and Occupational Health, School of Medicine, Toho University
    • Ishii Yoshikazu
    • Department of Microbiology and Infectious Diseases, School of Medicine, Toho University
    • Tateda Kazuhiro
    • Department of Microbiology and Infectious Diseases, School of Medicine, Toho University
    • Ebata Akiko
    • Department of Bacteriology, Ageo Medical Laboratories, Inc.
    • Iida Masaei
    • Department of Bacteriology, Ageo Medical Laboratories, Inc.
    • Mizuno Fumie
    • Department of Otorhinolaryngology, Hasuda Issinkai Hospital
    • Takahata Kaori
    • Department of Pediatrics, Tokyo Women's Medical University Medical Center East

Abstract

In this study, we prospectively investigated changes in <i>Streptococcus pneumoniae</i> serotypes among Japanese children after heptavalent pneumococcal conjugate vaccine (PCV7) inoculation. We acquired nasopharyngeal swabs from the children at each routine PCV7 inoculation and again at least 2 months after the last PCV7 inoculation. We defined 2 periods with regard to each culture: the inoculation period as “the period of pre- or incomplete vaccination” and post-inoculation as “the period of post- or completed vaccination.” The prevalence of vaccine-type (VT) pneumococci was significantly reduced from 9.5% in the inoculation-period cultures to 2.9% in the post-inoculation cultures (<i>P</i> < 0.01). There was no statistical difference in the prevalence of non-vaccine-type pneumococci between the inoculation-period and post-inoculation cultures (24.1% versus 23.4%). The protection of PCV7 against nasopharyngeal colonization was inferred from the decrease in VT carriage post-inoculation. The decrease in VT carriage may be conducive to reducing VT transmission within the study area.

Journal

  • Japanese Journal of Infectious Diseases

    Japanese Journal of Infectious Diseases 67(1), 40-43, 2014

    National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

Codes

  • NII Article ID (NAID)
    130003399229
  • NII NACSIS-CAT ID (NCID)
    AA1132885X
  • Text Lang
    ENG
  • ISSN
    1344-6304
  • NDL Article ID
    025176447
  • NDL Call No.
    Z53-C450
  • Data Source
    NDL  J-STAGE 
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