Urinary Excretion of O-Hydroxylysylglycosides in Diabetes Mellitus

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  • SATO TOKUTARO
    Department of Internal Medicine, Tohoku University School of Medicine
  • SAITO TSUYOSHI
    Department of Internal Medicine, Tohoku University School of Medicine
  • KOKUBUN MASARU
    Department of Internal Medicine, Tohoku University School of Medicine
  • ITO MASAAKI
    Department of Internal Medicine, Tohoku University School of Medicine
  • INOUE MICHIKO
    Department of Internal Medicine, Tohoku University School of Medicine
  • SAITO KAZUKO
    Department of Internal Medicine, Tohoku University School of Medicine
  • YOSHINAGA KAORU
    Department of Internal Medicine, Tohoku University School of Medicine

抄録

In order to study the metabolism of collagenous proteins in diabetes mellitus, urinary excretion of O-hydroxylysylglycosides, a characteristic component of collagenous protein, was determined in diabetics and controls. There was no significant correlation between urinary excretion rate of O-hydroxylysylglycosides and age (γ=-0.40 for diabetics and γ=-0.15 for control). In 16 age-matched pairs, urinary excretion of O-hydroxylysylglycosides was less in diabetics than in control (0.78±0.18 (mean±S. D.) μmoles/m2 body surface. hr versus 0.92±0.18 μmoles/m2 body surface-hr, p<0.05). This result suggests that catabolism of collagenous protein decreases in diabetics.

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