Isolation of a new phenazine antibiotic, DOB-41, from Pseudomonas species.

• SHOJI JUN''ICHI

  Shionogi Research Laboratories, Shionogi & Co., Ltd.

• SAKAZAKI RYUJI

  Shionogi Research Laboratories, Shionogi & Co., Ltd.

• NAKAI HIROSHI

  Shionogi Research Laboratories, Shionogi & Co., Ltd.

• TERUI YOSHIHIRO

  Shionogi Research Laboratories, Shionogi & Co., Ltd.

• HATTORI TERUO

  Shionogi Research Laboratories, Shionogi & Co., Ltd.

• SHIRATORI OSAMU

  Shionogi Research Laboratories, Shionogi & Co., Ltd.

• KONDO EIJI

  Shionogi Research Laboratories, Shionogi & Co., Ltd.

• KONISHI TAKAO

  Aburahi Laboratories, Shionogi & Co., Ltd.

抄録

A new phenazine antibiotic, DOB-41, was isolated from the culture broth of a Pseudomonas strain. The antibiotic obtained as yellow crystals showed UV maxima at 255 nm and 370 nm. A molecular formula, C₁₉H₁₈N₂O₆, was indicated by elemental analysis and mass spectrometry. The structure was elucidated by X-ray diffraction analysis. The antibiotic exhibited inhibitory activity against Gram-positive bacteria, and antitumor effect against leukemia P388 in mice.

収録刊行物

• The Journal of Antibiotics

  The Journal of Antibiotics 41 (5), 589-594, 1988

  公益財団法人 日本感染症医薬品協会

キーワード

• Drug Discovery
• Pharmacology

詳細情報

• CRID: 1390282679126871936
• NII論文ID: 130003409816
• DOI: 10.7164/antibiotics.41.589
• COI: 1:CAS:528:DyaL1cXks12qurc%3D
• ISSN: 18811469
• ISSN: 00218820
• PubMed: 3384746
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可