Conversion of bialaphos to other oligopeptides containing phosphinothricin by Streptomyces hygroscopicus.

DOI
  • KUMADA YOICHI
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd. Present address: Research & Development Planning, Pharmaceutical Division
  • IMAI SATOSHI
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
  • NAGAOKA KOZO
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.

抄録

Two oligopeptides containing phosphinothricin were accumulated in the culture of bialaphos (BA) producer Streptomyces hygroscopicus SF1293 when large amount of BA was added to the culture at idio phase. One of the oligopeptides was a new substance, BA dimer (phosphinothricyl-alanyl-alanyl-phosphinothricyl-alanyl-alanine), and the other was a known substance called If (phosphinothricyl-alanyl-alanyl-phosphinothricin). Though BA none producing mutants which were blocked at the steps 1, 10 and 13, respectively in BA biosynthesis also converted BA to BA dimer and If, the mutants blocked at the step 11 (alanylation) could not curry out the conversion. Antibiotic activities of BA dimer and If were lower than 1/100 of BA.

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キーワード

詳細情報 詳細情報について

  • CRID
    1390001204146078976
  • NII論文ID
    130003410013
  • DOI
    10.7164/antibiotics.44.1006
  • ISSN
    18811469
    00218820
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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