Anguinomycins C and D, New Antitumor Antibiotics with Selective Cytotoxicity against Transformed Cells.
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- HAYAKAWA YOICHI
- Institute of Molecular and Cellular Biosciences, The University of Tokyo
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- SOHDA KIN-YA
- Institute of Molecular and Cellular Biosciences, The University of Tokyo
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- SHIN-YA KAZUO
- Institute of Molecular and Cellular Biosciences, The University of Tokyo
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- HIDAKA TOMOMI
- Institute of Molecular and Cellular Biosciences, The University of Tokyo
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- SETO HARUO
- Institute of Molecular and Cellular Biosciences, The University of Tokyo
抄録
The retinoblastoma protein (pRB) is inactivated during the development of a wide variety of human cancers. In the course of our screening for antitumor antibiotics by using pRB-inactivated cells, an actinomycete strain was found to produce two active substances, which were elucidated to be new members of the leptomycin-anguinomycin family by NMR spectral analysis and were designated anguinomycins C and D. The anguinomycins induced growth arrest against normal cells and induced cell death against transformed cells, in which pRB was inactivated by viral oncoproteins such as human papilloma virus E7, adeno virus El A and simian virus 40 large T antigen.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 48 (9), 954-961, 1995
公益財団法人 日本感染症医薬品協会