Zelkovamycin, a New Cyclic Peptide Antibiotic from Streptomyces sp. K96-0670. II. Structure Elucidation.

• TABATA NORIKO

  Research Center for Biological Function, The Kitasato Institute and Graduate School of Pharmaceutical Sciences, Kitasato University

• TOMODA HIROSHI

  Research Center for Biological Function, The Kitasato Institute and Graduate School of Pharmaceutical Sciences, Kitasato University

• ZHANG HUA

  Research Center for Biological Function, The Kitasato Institute and Graduate School of Pharmaceutical Sciences, Kitasato University

• UCHIDA RYUJI

  Research Center for Biological Function, The Kitasato Institute and Graduate School of Pharmaceutical Sciences, Kitasato University

• OMURA SATOSHI

  Research Center for Biological Function, The Kitasato Institute and Graduate School of Pharmaceutical Sciences, Kitasato University

書誌事項

タイトル別名

• II. Structure Elucidation

抄録

The structure of antibiotic zelkovamycin was elucidated as a cyclic pep tide comprising glycyl, 2-aminobutanoyl, 2-ammo-2-butenoyl, N-methyl glycyl, alanyl, 1, 3-thiazoyl, 7-methoxytryptophanyl and 2-methyldehydrothreonyl residues. The sequence of the amino acids was established by spectroscopic studies including ¹H-¹H COSY, ¹³C-¹H COSY, ¹³C-¹H HMQC, ¹³C-¹H HMBC, ¹⁵N-¹H HMQC and ¹⁵N-¹H HMBC NMR experiments.

収録刊行物

• The Journal of Antibiotics

  The Journal of Antibiotics 52 (1), 34-39, 1999

  公益財団法人 日本感染症医薬品協会

キーワード

• Drug Discovery
• Pharmacology

詳細情報

• CRID: 1390001204151257600
• NII論文ID: 130003410325
• DOI: 10.7164/antibiotics.52.34
• COI: 1:CAS:528:DyaK1MXpsFGktg%3D%3D
• ISSN: 18811469
• ISSN: 00218820
• PubMed: 10092195
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
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