Chlorogentisylquinone, a New Neutral Sphingomyelinase Inhibitor, Produced by a Marine Fungus.

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Author(s)

    • UCHIDA RYUJI
    • Kitasato Institute for Life Sciences, Kitasato University and The Kitasato Institute
    • TOMODA HIROSHI
    • Kitasato Institute for Life Sciences, Kitasato University and The Kitasato Institute
    • ARAI MASAYOSHI
    • Kitasato Institute for Life Sciences, Kitasato University and The Kitasato Institute
    • OMURA SATOSHI
    • Kitasato Institute for Life Sciences, Kitasato University and The Kitasato Institute

Abstract

Chlorogentisylquinone, a new inhibitor of neutral Sphingomyelinase activity, was purified from the culture broth of a fungal strain FOM-8108 isolated from a marine environment by solvent extraction, silica gel chromatography and Sephadex LH-20 chromatography. Its chemical structure was elucidated by spectroscopic studies including <sup>1</sup>H, <sup>13</sup>C, DEPT, HMQC and HMBC NMR experiments. Chlorogentisylquinone inhibited neutral Sphingomyelinase activity of rat brain membranes with an IC<sub>50</sub> value of 1.2μM.

Journal

  • The Journal of Antibiotics

    The Journal of Antibiotics 54(11), 882-889, 2001

    JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

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