New Pyrrolizidinone Antibiotics CJ-16,264 and CJ-16,367.

• SUGIE YUTAKA

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.

• HIRAI HIDEO

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.

• KACHI-TONAI HIROKO

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.

• KIM YOON-JEONG

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.

• KOJIMA YASUHIRO

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.

• SHIOMI YUKIO

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.

• SUGIURA AKEMI

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.

• SUGIURA AYUMU

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.

• SUZUKI YUMIKO

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.

• YQSHIKAWA NOBUJI

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.

• BRENNAN LORI

  PGRD, Groton Laboratories, Pfizer Inc.

• DUIGNAN JOAN

  PGRD, Groton Laboratories, Pfizer Inc.

• HUANG LIANG HSIUNG

  PGRD, Groton Laboratories, Pfizer Inc.

• SUTCLIFFE JOYCE

  PGRD, Groton Laboratories, Pfizer Inc.

• KOJIMA NAKAO

  Faculty of Pharmacy, Meijo University

抄録

Two new antibiotics, CJ-16, 264 (I) and CJ-16, 367 (II), were isolated from the fermentation broth of an unidentified fungus CL39457. These antibiotics have a pyrrolizidinone skeleton, first discovered in fungi. Compounds I and II inhibit the growth of Gram-positive multi-drug resistant bacteria and some Gram-negative strains such as Moraxella catarrhalis and Escherichia coli with altered permeability (imp). Comparison of an antibacterial profile between the two compounds suggested that the gamma-lactone portion of I is important for the activity.

収録刊行物

• The Journal of Antibiotics

  The Journal of Antibiotics 54 (11), 917-925, 2001

  公益財団法人 日本感染症医薬品協会

キーワード

• Drug Discovery
• Pharmacology

詳細情報

• CRID: 1390001204150886656
• NII論文ID: 130003410396
• NII論文ID: 10008471343
• NII書誌ID: AA0069330X
• DOI: 10.7164/antibiotics.54.917
• COI: 1:CAS:528:DC%2BD3MXovVOru7s%3D
• ISSN: 18811469
• ISSN: 00218820
• PubMed: 11827034
• Web Site: https://search.jamas.or.jp/link/ui/2002118051
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可