A New Effective and Convenient Route to Fluorinated Nitrogen Heterocyclic Compounds by the Use of Enol Phosphates Derived from <i>F</i>-Alkyl Ketones

DOI PDF 参考文献17件
  • Takashi Ishihara
    Department of Industrial Chemistry, Faculty of Engineering, Kyoto University
  • Yoshiji Okada
    Department of Industrial Chemistry, Faculty of Engineering, Kyoto University
  • Manabu Kuroboshi
    Department of Industrial Chemistry, Faculty of Engineering, Kyoto University
  • Takao Shinozaki
    Department of Industrial Chemistry, Faculty of Engineering, Kyoto University
  • Teiichi Ando
    Department of Industrial Chemistry, Faculty of Engineering, Kyoto University

抄録

<jats:title>Abstract</jats:title> <jats:p>The treatment of F-alkyl ketones with sodium diethyl phosphite in tetrahydrofuran at −10 to 0 °C gave high yields of 1-substituted F-1-alkenyl phosphates, which readily reacted with amidine or hydrazine derivatives at room temperature to afford the corresponding fluorinated pyrimidines or pyrazoles, respectively, in good to excellent yields.</jats:p>

収録刊行物

  • Chemistry Letters

    Chemistry Letters 17 (5), 819-822, 1988-05

    Oxford University Press (OUP)

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