Resonance Raman Spectra of Manganese-Porphyrins on Ion-Exchange Resins Exhibiting Uricase-Like Catalytic Activity.

• ODO Junichi

  Faculty of Pharmaceutical Sciences, Okayama University

• MIFUNE Masaki

  Faculty of Pharmaceutical Sciences, Okayama University

• IWADO Akimasa

  Faculty of Pharmaceutical Sciences, Okayama University

• KARASUDANI Tatsuya

  Faculty of Pharmaceutical Sciences, Okayama University

• HASHIMOTO Hirotaka

  Faculty of Pharmaceutical Sciences, Okayama University

• MOTOHASHI Noriko

  Kobe Women's College of Pharmacy

• TANAKA Yoshimasa

  Faculty of Pharmaceutical Sciences, Okayama University

• SAITO Yutaka

  Faculty of Pharmaceutical Sciences, Okayama University

抄録

Ion-exchange resins modified with some manganese(III)-porphyrins (Mn³⁺-P_r) show a uricase-like catalytic activity, which is applicable to the determination of uric acid. The resonance Raman spectra of Mn³⁺-P_r indicate that Mn³⁺- porphyrins on modified resins are reduced to Mn²⁺-porphyrins with oxidizing uric acid; Mn²⁺-porphyrins then return to Mn³⁺-porphyrins by oxidation with O₂ in the reaction system. It was concluded on the basis of these results that the modified resins show an uricase-like activity by repeating this redox cycle of manganese-porphyrins on the modified resins. Mn³⁺-P_r exhibited no oxidative catalytic activity for 7-methylated derivatives of uric acid, indicating that the nitrogen atom at the 7-position of uric acid plays an important role in the activity of Mn³⁺-P_r.

収録刊行物

• Analytical Sciences

  Analytical Sciences 7 (4), 555-559, 1991

  社団法人 日本分析化学会

キーワード

• Modified resin
• uricase-like activity
• uric acid
• resonance Raman spectrum
• porphyrin-core vibration
• manganese-porphyrin

詳細情報

• CRID: 1390282679234164992
• NII論文ID: 130003416785
• DOI: 10.2116/analsci.7.555
• COI: 1:CAS:528:DyaK38XhslOisg%3D%3D
• ISSN: 13482246
• ISSN: 09106340
• Web Site: https://link.springer.com/content/pdf/10.2116/analsci.7.555.pdf
• Web Site: https://link.springer.com/article/10.2116/analsci.7.555/fulltext.html
• Web Site: http://www.jstage.jst.go.jp/article/analsci1985/7/4/7_4_555/_pdf
• 本文言語コード: en
• データソース種別:
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