Differential development of antioxidant enzymes in liver of female and castrated and non-castrated male rats.

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抄録

Females are postulated to have a higher antioxidant capacity than males, this increase thereby allowing them to live longer than males. To determine whether this heightened capacity can be attributed to the difference in tissue levels of antioxidant enzymes, we investigated age-and sex-related differences in four antioxidant enzymes in developing rat livers. Female and non-castrated and castrated male rats, ages ranging from 3 to 10 weeks, were studied. Both copper zinc (CuZn) and manganese (Mn) superoxide dismutases (SOD) were assayed by specific radioimmunoassays. Body weight and liver weight were larger in non-castrated males than in females. Glutathione peroxidase activity was higher in females than in males even at 3 weeks of age, and the difference became more evident as the rats grew older. Conversely, catalase activity was higher in males than in females. The values of body weight, liver weight, glutathione peroxidase, and catalase in castrated males were between those of non-castrated males and females, suggesting a significant contribution of endogenous sex hormones to these changes. CuZnSOD increased during maturation in both sexes, while MnSOD did not. There was no significant sex-related difference in SODs. Possible physiological consequence of the relative richness of glutathione peroxidase in females was discussed.

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詳細情報 詳細情報について

  • CRID
    1390282679649147392
  • NII論文ID
    130003448910
  • DOI
    10.3164/jcbn.9.87
  • ISSN
    18805086
    09120009
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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