牛における全身性アミロイド沈着症の臨床並びに臨床病理学的所見

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  • Clinical and Clinico-Pathological Observations of Generalized Amyloidosis in Cattle
  • ウシ ニ オケル ゼンシンセイ アミロイド チンチャクショウ ノ リンショウ

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Clinical and clinico-pathological observations were made on three cattle affected with generalized amyloidosis. The results obtained are as follows. 1. The main clinical symptoms of the three cattle were anorexia, continued watery diarrhea, edema of the subcutaneous tissue, and rapid emaciation. The clinical duration was 13 to 34 days. Prognosis was bad without any therapeutic effect in all the cattle. 2. The characteristic biochemical findings were advanced hypoproteinemia accompanied by hypoalbuminemia, hypobetaglobulinemia, hypogammaglobulinemia and hyperalphaglobulinemia. In the immunoelectrophoretic pattern of serum, precipitin lines were strong for alpha 1 lipoprotein and alpha 2 macroglobulin and mild for albumin and IgG. 3. Advanced renal proteinuria was shown by the urine which contained such protein components as albumin, alpha-, beta- and gammaglobulin. In the urinary sediment, there were renal epithelial cells, hyaline casts and leukocytes in all cases. 4. Severe amyloidosis was observed in all the affected cattle. Amyloid deposits were found in the wall of small blood vessels in almost all the organs, including the liver, spleen, pancreas, adrenal cortex, lymph nodes, alimentary tract and thyroid gland. The alimentary tract showed serious edematous changes in the submucosal tissue. In addition, there were multiple abscesses in the lungs (Case No.1), chronic mastitis and suppurative peritonitis (Case No.2) and chronic mastitis (Case No.3). 5. No incidental causes of generalized amyloidosis were unknown in any case. It was suggested that the disease might follow the chronic infections described above.

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