イヌにおける抗尿細管上皮ウサギ血清による間質性腎炎の惹起

DOI 日本農学文献記事索引 Web Site Web Site PubMed

書誌事項

タイトル別名
  • Induction of Interstitial Nephritis in Dogs Treated with Rabbit Antiserum against Renal Tubular Epithelium
  • イヌ ニ オケル コウ ニョウサイカン ジョウヒ ウサギ ケッセイ ニヨル カ

この論文をさがす

抄録

Interstitial nephritis was induced in 7 of 8 and 3 of 4 dogs by intravenous and renoarterial administration, respectively, with rabbit antiserum against canine renal tubular epithelium. The lesions consisted of tubular damage and focal monontlclcar cell infiltration in the cortical interstitium, varying in intensity among cases. No such inter-stitial lesions were detected in control animals receiving normal rabbit serum. Electron microscopy revealed infiltration of medium- and large-sized lymphoid cells, sometimes in close contact with the tubular basement membrane (TBM). There were, however, no immune of fluorescence for rabbit IgG or electron-dense deposits in TBM. In intravenously-treated cases, glomermar hypercellularity was also observed following the appearance of interstitial lesions, but it seemed to represent a reaction to neterologous serum injection.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ