感染防御機構低下動物における感染 : Proteus morganii 1510株に対する担癌マウスのオプソニン抗体形成の抑制

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  • Infections in compromised hosts: Impairment of antibody for opsonization of Proteus morganii strain 1510 in tomor-bearing mice.
  • 感染防御機構低下動物における感染--Proteus morganii1510株に対する担癌マウスのオプソニン抗体形成の抑制〔英文〕
  • カンセン ボウギョ キコウ テイカ ドウブツ ニ オケル カンセン Prote

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When live or killed Proteus morganii, strain 1510, was inoculated intravenously to normal mice, serum factors for opsonization of the inoculated bacteria increased daily from the 2nd day of postinoculation. After inoculation with killed cells, the serum factors did not increase in Sarcoma-180 tumor-bearing mice. When the immune serum from normal mice inoculated with P. morganii was pretreated with anti-mouse IgG or anti-mouse IgM, opsonic activity markedly decreased. Although no opsonic activity was noted in heat-inactivated immune serum, when tumor-bearing mouse serum as a complement was added to inactivated immune serum, opsonic value recovered. The immune serum from normal mice after 3 days postinoculation demonstrated significant protection against challenge with the same bacteria in tumor-bearing mice when passively transferred, but serum from tumor-bearing mice inocultated with P. morganii did not indicate protective effect. When the immune serum was treated with anti-mouse IgM, protection against challenge decreased significantly. However, there was no significant difference between immune serum treated with anti-mouse IgG and untreated immune serum. It was found that IgM antibody necessary for optimal opsonization and protection was markedly impaired in tumor-bearing mice.

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