Pathologic observations of mouse liver infected with Tyzzer's organisms using immunoperoxidase method.

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  • Tyzzer菌感染マウス肝の免疫酵素抗体法による病理学的観察
  • Tyzzer菌感染マウス肝の免疫酵素抗体法による病理学的観察〔英文〕
  • Tyzzerキン カンセン マウス カン ノ メンエキ コウソ コウタイホウ

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Abstract

Using immunoperoxidase method the production of liver lesions and propagation of organisms were observed in mice intravenously inoculated with MSK strain of Tyzzer's organisms and treated with cortisone. Microbial antigen was first detected on Day 2 postinoculation (p.i.) within very small necrotized foci. On Day 3 p.i. or later when necrotic foci with neutrophil infiltration increased in size and number, many immunoperoxidase-positive bacteria were present within seemingly living hepatocytes at the periphery of lesions but not within the necrotized foci. Apart from large-sized necrotized foci some hepatocytes carrying abundant bacterial antigen were singly present without inducing any mesenchymal response. At the moribund stage, neutrophils as well as Kupffer cells were found to carry bacterial antigen in the sinusoidal spaces without showing morphologic evidence of bacterial growth. Electron microscopy revealed that antibody specifically combined with the flagella and bacterial surface.

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