コロイダルカーボンおよび赤血球を投与したニワトリ肝臓におけるリンパ球集簇内へのKupffer細胞の集積

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タイトル別名
  • Accumulation of Kupffer cells within lymphocyte aggregates in the livers of chickens injected with colloidal carbon and erythrocytes.
  • コロイダルカーボンおよび赤血球を投与したニワトリ肝臓におけるリンパ球集簇内へのKupffer細胞の集積〔英文〕
  • コロイダル カーボン オヨビ セッケッキュウ オ トウヨシタ ニワトリ カンゾ

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Chicken livers were observed under light and electron microscopes at various time intervals after i. v. injection of colloidal carbon and glutaraldehyde-treated goat or rat erythrocytes. In the chicken liver, lymphocyte aggregates which mainly consisted of T-lymphocytes were always found in the space of Disse and interlobular connective tissue. Kupffer cells ingested a large number of carbon particles or erythrocytes in their cytoplasm at 5 min after injection. After 1 to 3 days, carbon-laden Kupffer cells moved from the sinusoids into the space of Disse, and initially accumulated around lymphocyte aggregates. Thereafter carbon-laden Kupffer cells stayed within lymphocyte aggregates for 7 to 21 days. Erythrocyte-ingesting Kupffer cells also migrated to accumulate in the lymphocyte aggregates after 1 day. Sinusoidal endothelial cells also ingested a small amount of carbon particles, but neither took up erythrocytes nor migrated into the space of Disse unlike Kupffer cells. Macrophage-T lymphocyte interaction was suggested by the accumulation of phagocytic Kupffer cells within the lymphocyte aggregate.

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