マウスにおけるDDTおよびdieldrinの神経作用
書誌事項
- タイトル別名
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- Characteristics of neuronal effects of DDT and dieldrin in mice.
- マウスにおけるDDTおよびdieldrinの神経作用〔英文〕
- マウス ニ オケル DDT オヨビ dieldrin ノ シンケイ サヨウ エ
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Neurotoxic effects of clofenotane (DDT) and dieldrin were analyzed pharmacologically in mice. Oral (p. o.) or intravenous (i. v.) administration of DDT caused the tremor, while dieldrin caused the tonic or clonic convulsion. Intracerebroventricular (i. c. v.) injection of both agents also caused the neurotoxic symptoms which were qualitatively similar to those shown after p. o. or i. v. administration. These effects may be central nervous system in origin since i. v. injection of either insecticides had no direct effect on sciatic nerve-gastrocnemius muscle system after the nerve had been sectioned. The tremor due to DDT was aggravated by dopaminergic antagonist but unaffected by muscarinic antagonist. The convulsion due to dieldrin was alleviated by muscarinic or dopaminergic antagonist but aggravated by adrenergic or GABA ergic antagonist. These differences suggest that DDT and dieldrin develop their neurotoxic symptoms through different neural pathway(s).
収録刊行物
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- 日本獸醫學雜誌(The Japanese Journal of Veterinary Science)
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日本獸醫學雜誌(The Japanese Journal of Veterinary Science) 49 (6), 1039-1044, 1987
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206423856896
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- NII論文ID
- 110003917671
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- NII書誌ID
- AN00191788
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- COI
- 1:CAS:528:DyaL1cXhsVGjt70%3D
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- ISSN
- 18811442
- 00215295
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- NDL書誌ID
- 3173348
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- PubMed
- 3430915
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可