牛白血病ウイルス接種により起こる牛の持続性リンパ球増多症とその継代

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  • Development and serial passage of persistent lymphocytosis associated with bovine leukemia virus infection in cattle.
  • 牛白血病ウイルス接種により起こる牛の持続性リンパ球増多症とその継代〔英文〕
  • ウシ ハッケツビョウ ウイルス セッシュ ニ ヨリ オコル ウシ ノ ジゾクセ

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Two calves each were inoculated with 1.5×108 or 5×109 lymphocytes collected from each one cow which had persistent lymphocytosis (PL) and antibodies to bovine leukemia virus (BLV). A sudden increase in the number of peripheral blood lymphocytes (PBL) was observed 14 and 23 days, respectively, after inoculation and the maximum number reached 29, 000 and 52, 000/μl 72 and 57 days after inoculation. Although the degree of PL decreased gradually in these cattle, it continued until 14 and 44 months after inoculation when one animal was sacrificed and the other died of lymphosarcoma. The PL was passaged in cattle by inoculation of a large number of PBL obtained from cattle at the stage of PL (PLL). The degree of PL was severer in cattle inoculated with a larger number of PLL. PL was not caused by inoculation of PBL obtained from either BLV-infected non-PL cattle or cattle free of BLV. The PL was also caused by inoculation of PLL into BLV-infected non-PL cattle. On the other hand, it was not observed after inoculation of a large amount of cell-free virus obtained from short-term cultures of PLL. Antibodies to BLV developed earlier and to higher levels in cattle inoculated with PLL than in those inoculated with cell-free virus. These facts show that infection with BLV was established more effectively by PLL than by cell-free virus, the infection may occur by lymphocyte to lymphocyte interaction and the actual number of infected BLV may have an important role in development of PL.

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