猫免疫不全ウイルス感染猫における末梢血リンパ球幼若化反応の変化

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タイトル別名
  • Altered mitogen response of peripheral blood lymphocytes in different stages of feline immunodeficiency virus infection.
  • 猫免疫不全ウイルス感染猫における末梢血リンパ球幼若化反応の変化〔英文〕
  • ネコ メンエキ フゼン ウイルス カンセン ネコ ニ オケル マッショウケツ

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To elucidate relationship between disease progress and immunologic alteration in feline immunodeficiency virus (FIV) infection, we classified naturally infected cats into clinical stage groups using the working criteria modified from those for human immunodeficiency virus (HIV) infection. Among the five distinct staged described for HIV infection, the three phases; asymptomatic carrier (AC), AIDS related complex (ARC), and acquired immunodeficiency syndrome (AIDS), were evaluated for concanavalin A (Con A)-induced lymphocyte blastogenic activities by using glucose consumption assay. There was a significant decrease of lymphocyte response in AC phase. The loss of response became marked as the disease progressed to ARC and AIDS, with an almost complete loss of mitogen response in AIDS phase. In addition to the loss of a lymphocyte function, AIDS in FIV infection was characterized by marked emaciation, anemia or pancytopenia, and postmortem evidences of opportunistic infections and lymphoid depletion.

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