Complement-Dependent Cytotoxicity of Sera Obtained from Subacute Sclerosing Panencephalitis Patients
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- KUWAJIMA Shigeru
- Department of Microbiology, Hokkaido University School of Medicine
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- MINAGAWA Tomonori
- Department of Microbiology, Hokkaido University School of Medicine
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- FUJII Nobuhiro
- Department of Microbiology, Hokkaido University School of Medicine
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- IIDA Hiroo
- Department of Microbiology, Hokkaido University School of Medicine
抄録
Human lymphoid cells (NC-37) persistently infected with either measles virus (Schwarz and TYCSA strains) or subacute sclerosing panencephalitis (SSPE) virus (Halle and Mantooth strains) were destroyed in the presence of complement by anti-measles sera as well as by sera from SSPE patients. The cytotoxic activity was demonstrated in both IgG and IgM fractions of measles convalescent sera, but only in IgG fraction of SSPE sera. Measles convalescent sera completely lost the cytotoxic activity to all the cell lines, when absorbed with any one of the cell lines, indicating that the viral surface antigens of these cell lines infected with measles or SSPE virus are identical. On the other hand, the cytotoxic activity of SSPE sera could not be readily absorbed with these cells. Thus, the affinity of SSPE sera for the viral surface antigens might be lower than that of measles convalescent sera.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 22 (3), 143-153, 1978
Center For Academic Publications Japan
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詳細情報 詳細情報について
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- CRID
- 1573387452895056512
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- NII論文ID
- 130003482698
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles