Endotoxic Glycolipid as a Potent Depressor of the Hepatic Drug‐Metabolizing Enzyme Systems in Mice*

• EGAWA Kiyoshi

• KASAI Nobuhiko

  Department of Microbial Chemistry, School of Pharmaceutical Sciences, Showa University

書誌事項

タイトル別名

• Endotoxic Glycolipid as a Potent Depressor of the Hepatic Drug-Metabolizing Enzyme Systems in Mice
• Endotoxic Glycolipid as a Potent Depres

抄録

Inhibitory effects of the endotoxic glycolipid from Salmonella minnesota R595 on hepatic drug-metabolizing enzyme activities in mice were investigated, and the depressor activity of the glycolipid in the enzyme systems was confirmed. Among degradation products of lipopolysaccharides tested, lipid A preparations derived from the mild acetic acid hydrolysates of lipopolysaccharides were the most active, but the lipid A fractions prepared from the hydrolysates with 1 N-HCl were almost inactive. A degraded polysaccharide fraction from E. coli lipopolysaccharide was inactive. The activities of the glycolipid and the lipid A preparation were markedly reduced by treatment with alkaline-hydroxylamine, mild alkali or hydrazine. The data showed that the lipid A moiety of the glycolipid may be responsible for the inhibitory activity on the hepatic drug-metabolizing enzyme systems.

収録刊行物

• MICROBIOLOGY and IMMUNOLOGY

  MICROBIOLOGY and IMMUNOLOGY 23 (2), 87-94, 1979

  財団法人 学会誌刊行センター

キーワード

• Virology
• Immunology
• Microbiology

詳細情報

• CRID: 1390001206322658560
• NII論文ID: 130003482779
• NII書誌ID: AA00738350
• DOI: 10.1111/j.1348-0421.1979.tb00444.x
• COI: 1:CAS:528:DyaE1MXksFSkur8%3D
• ISSN: 13480421
• ISSN: 03855600
• NDL書誌ID: 2079831
• PubMed: 459949
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I2079831
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1348-0421.1979.tb00444.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1348-0421.1979.tb00444.x
• 本文言語コード: en
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