Microbial Adjuvant and Autoimmunity-4-Production of Lesions in the Exocrine Pancreas of Mice by Repeated Injection of Syngeneic Pancreatic Extract Together with the Capsular Polysaccharide of Klebsiella pneumoniae

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  • YAMAKI Kenichi
    Department of Pathology, Nagoya University School of Medicine
  • OHTA Michio
    Department of Pathology, Nagoya University School of Medicine
  • NAKASHIMA Izumi
    Department of Pathology, Nagoya University School of Medicine
  • NODA Aiji
    Department of Pathology, Nagoya University School of Medicine
  • ASAI Junpei
    Department of Pathology, Nagoya University School of Medicine
  • KATO Nobuo
    Department of Bacteriology, Second Department of Internal Medicine

書誌事項

タイトル別名
  • Microbial Adjuvant and Autoimmunity
  • Microbial Adjuvant and Autoimmunity 4 P
  • Microbial adjuvant and autoimmunity. IV. Production of lesions in the exocrine pancreas of mice by repeated injection of syngeneic pancreatic extract together with the capsular polysaccharide of Klebsiella pneumoniae

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Definite lesions in the exocrine pancreas were produced when SMA mice were immunized eight times at intervals of 30 days with a mixture of extract of pooled pancreas from syngeneic mice and the capsular polysaccharide of Klebsiella pneumoniae type 1 Kasuya strain (CPS-K), whereas no pancreatic lesions were produced in mice given CPS-K alone or pancreatic extract alone. The typical histological changes were characterized by infiltration with lymphocytes, plasma cells, and other mononuclear cells, degeneration and lysis of the acinar cells, destruction of the lobular architecture, and replacement by fatty tissue and fibrous connective tissue. The endocrine islets were well preserved. No specific histological changes were produced in the organs other than the pancreas in these mice. Most of mice immunized with pancreatic extract mixed with CPS-K produced serum precipitins to syngeneic pancreatic antigens. However, severe pancreatic lesions were also produced in mice showing no definite precipitin production.

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