Immunogenicity and Protective Effect of Hemolysis Mutants of <i>Mycoplasma pneumoniae</i>

• YAYOSHI Masumi

  Department of Microbiology, Tokyo Women's Medical College

• ARAAKE Minako

  Department of Microbiology, Tokyo Women's Medical College

• HAYATSU Eizo

  The Kitasato Institute

• TAKEZAWA Toshiyuki

  The Kitasato Institute

• YOSHIOKA Morimasa

  Department of Microbiology, Tokyo Women's Medical College

抄録

Two attenuated strains of Mycoplasma pneumoniae, P24-S1 and P24-S11, were tested for their ability as a live vaccine to confer on hamsters immune resistance against challenge infection with a virulent strain of M. pneumoniae, FH-P24. Fifty percent protection was obtained by vaccination with the P24-S1 strain administered once or twice. In contrast, only 10% of the animals were protected by the P24-S11 vaccine even when it was given three times. Vaccination with the P24-S1 strain resulted in higher humoral and cellular immune responses than the P24-S11 did. These results suggest that the P24-S1 strain has the primary qualities a vaccine which may be used for protection against human mycoplasmal infection.

収録刊行物

• MICROBIOLOGY and IMMUNOLOGY

  MICROBIOLOGY and IMMUNOLOGY 29 (11), 1029-1037, 1985

  Center For Academic Publications Japan

詳細情報

• CRID: 1573668927871837824
• NII論文ID: 130003483072
• ISSN: 03855600
• Web Site: https://jlc.jst.go.jp/DN/JALC/00170735658?from=CiNii
• 本文言語コード: en
• データソース種別:
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