Immunomodulation in Mice by Experimental Infection with <i>Yersinia enterocolitica</i>
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- RUIZ-BRAVO Alfonso
- Departamento de Microbiologia, Facultad de Farmacia, Universidad de Granada
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- JIMENEZ-VALERA María
- Departamento de Microbiologia, Facultad de Farmacia, Universidad de Granada
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- CIENFUEGOS Gerardo Alvarez DE
- Departamento de Microbiologia, Facultad de Farmacia, Universidad de Granada
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- RUIZ Concepción
- Departamento de Microbiologia, Facultad de Farmacia, Universidad de Granada
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- KOUWATLI Khalil
- Departamento de Microbiologia, Facultad de Farmacia, Universidad de Granada
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- RAMOS-CORMENZANA Alberto
- Departamento de Microbiologia, Facultad de Farmacia, Universidad de Granada
抄録
Intraperitoneal infection of mice with two strains of Yersinia enterocolitica resulted in an inflammatory response and immunomodulation which appeared to be related to the invasive properties of the bacteria. The primary antibody response to sheep erythrocytes was enhanced by noninvasive cultures of Y. enterocolitica (serotype O:4-33 grown at 22C and at 37C, and serotype O:3 grown at 37C), when given at the same time or two days after the antigen (invasiveness was tested on HeLa cells). In contrast, invasive cultures of serotype O:3 grown at 22C, injected three days before the antigen suppressed the antibody response; enhancement was caused by these cultures only when given on the day of immunization. Delayed-type hypersensitivity to sheep erythrocytes was also suppressed by invasive cultures of Y. enterccolitica. These data indicate that the temperature of growth as well as some serotype-linked factors play a role in immunomodulation by Y. enterocolitica.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 29 (11), 1089-1097, 1985
Center For Academic Publications Japan
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詳細情報 詳細情報について
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- CRID
- 1570009753174592896
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- NII論文ID
- 130003483078
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles