Role of Interleukin 2 on Enhancement of Concanavalin A-Induced Human Peripheral Blood Lymphocyte Proliferation by Murine B Cell Mitogens

• NITTA Toshimasa

  Department of Bacteriology, Tohoku Dental University

• KONNO-EJIRI Hiromi

  Department of Bacteriology, Tohoku Dental University

• OKUMURA Seiichi

  Department of Bacteriology, Tohoku Dental University

• OZAWA Atsushi

  Department of Microbiology, Tokai University School of Medicine

• NAKANO Masayasu

  Department of Microbiology, Jichi Medical School

抄録

Murine B cell mitogens such as bacterial lipopolysaccharide (LPS), butanol-extracted water soluble adjuvant (Bu-WSA), dextran sulfate (DS), synthetic muramyl dipeptide (MDP), and its analog MDP-Lys (L18) do not show any mitogenic ability in vitro on human peripheral blood lymphocytes or mixed cell populations of purified T and B cells obtained from the lymphocytes in an ordinary culture system. However, these mitogens are capable of enhancing the mitogenic effect of concanavalin A (Con A) in the cultures.<br>In the presence of one of these mitogens, the activity of interleukin 2 (IL 2), but not interleukin 1, in the supernatants obtained from cultures containing Con A-stimulated T cell and B cell populations was higher than that of control cultures. The role of the newly produced IL 2 in the synergistic effect of the mitogens in human lymphocyte cell cultures was discussed.

収録刊行物

• MICROBIOLOGY and IMMUNOLOGY

  MICROBIOLOGY and IMMUNOLOGY 29 (5), 441-449, 1985

  Center For Academic Publications Japan

詳細情報

• CRID: 1571135653080917376
• NII論文ID: 130003483132
• ISSN: 03855600
• Web Site: https://jlc.jst.go.jp/DN/JALC/00170269795?from=CiNii
• 本文言語コード: en
• データソース種別:
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