Increased Resistance to <i>Salmonella</i> Infection of Hypoferremic Mice Fed a Low-Protein Diet
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- GAUTHIER Yves
- Division de Microbiologie, Centre de Recherches du Service de Santé des Armées
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- ISOARD Pierre
- Division de Microbiologie, Centre de Recherches du Service de Santé des Armées
抄録
BALB/c and CBA/CA mice fed a protein-deficient diet developed a plasma hypoferremia corresponding to a 30 percent lowering of serum iron concentration. This hypoferremia persisted as long as the diet was maintained. Hypoferremic CBA/CA mice had increased resistance to Salmonella typhimurium C5 infection, as shown by the reduced lethal activity and the decreased growth of the bacteria in the spleen and in the peritoneal exudate of the deficient animals. This induced resistance was abolished after injection of iron or Desferal into the restricted animals. Such resistance was not observed with BALB/c mice fed a protein-deficient diet, in spite of the plasma hypoferremia. The growth of S. typhimurium C5 in the spleen and in the peritoneal exudate of these animals did not differ from the growth observed in control animals fed a protein-sufficient diet. This study suggests that hypoferremia induced by a protein-deficient diet is probably involved in the enhancement of resistance of CBA/CA mice to Salmonella infection, and that the phenomenon is host-strain dependent.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 30 (5), 425-435, 1986
Center For Academic Publications Japan
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詳細情報 詳細情報について
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- CRID
- 1571135653081310592
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- NII論文ID
- 130003483218
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles