Lipid Metabolism in Endotoxic Rats: Decrease in Hepatic Triglyceride Lipase Activity

J-STAGE
  • KAWAKAMI Masanobu
    The Third Department of Internal Medicine, Faculty of Medicine, The University of Tokyo
  • MURASE Toshio
    The Third Department of Internal Medicine, Faculty of Medicine, The University of Tokyo
  • ITAKURA Hiroshige
    The Third Department of Internal Medicine, Faculty of Medicine, The University of Tokyo
  • YAMADA Nobuhiro
    The Third Department of Internal Medicine, Faculty of Medicine, The University of Tokyo
  • OHSAWA Nakaaki
    The Third Department of Internal Medicine, Faculty of Medicine, The University of Tokyo
  • TAKAKU Fumimaro
    The Third Department of Internal Medicine, Faculty of Medicine, The University of Tokyo

抄録

Studies were conducted to investigate the effect of E. coli endotoxin administration on hepatic triglyceride lipase (H-TGL) activity in rats, since H-TGL activity is known to behave differently from lipoprotein lipase (LPL) activity in various situations. Plasma triglyceride and free fatty acid concentrations were markedly elevated in animals after injection of endotoxin. Cholesterol and phospholipids were also increased significantly. Lipoprotein analysis by ultracentrifugation showed that the most pronounced increase of lipoproteins was in the VLDL and IDL fractions. Triglyceride lipase activities in post-heparin plasma were markedly decreased. A selective assay for H-TGL activity using a specific antibody revealed that this enzyme as well as LPL is significantly decreased (26% of control) in endotoxic animals. Thus, the increase of VLDL and IDL appears to result from the decrease of both of LPL and H-TGL.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ