Association of HLA DR1 with High D-Penicillamine Binding to Monocytes in Females
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- WATANABE Hiroshi
- Basic Research Department, Hoechst Japan
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- KELLY Heath
- The Departments of Clinical Immunology, The Queen Elizabeth II Medical Center and Royal Perth Hospital
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- DAWKINS Roger L.
- The Departments of Clinical Immunology, The Queen Elizabeth II Medical Center and Royal Perth Hospital
抄録
Binding of D-Penicillamine (D-Pen) to human monocytes was examined by flow cytometry with fluorescent D-Pen conjugate. Cells from HLA DR1-positive healthy females bound significantly more D-Pen than cells from DR1-negative healthy females (P=0.015), and DR1 was associated with the highest binding among HLA DR antigens. In contrast, DR4 was associated with the lowest binding in healthy females. A difference in D-Pen binding between healthy females who were DR1-positive, DR4-negative and those who were DR1-negative, DR4-positive was statistically significant (P=0.026). Neither healthy females nor healthy males showed significant associations of D-Pen binding with HLA A, B, or C antigens, nor did healthy males show an association between strength of D-Pen binding and any DR antigens.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 31 (1), 83-88, 1987
Center For Academic Publications Japan
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詳細情報 詳細情報について
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- CRID
- 1571698603034733184
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- NII論文ID
- 130003483283
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles