A Comparative Study of Alteration in Lymphocyte Subsets among Varicella, Hand-Foot-and-Mouth Disease, Scarlet Fever, Measles, and Kawasaki Disease

J-STAGE
  • YANASE Yoshio
    Department of Pediatrics, Japanese Red Cross Medical Center
  • TANGO Toshiro
    Department of Clinical Epidemiology, Tokyo Metropolitan Institute of Medical Science
  • OKUMURA Ko
    Department of Immunology, Juntendo University, School of Medicine
  • TADA Tomio
    Department of Immunology, Faculty of Medicine, The University of Tokyo
  • KAWASAKI Tomisaku
    Department of Pediatrics, Japanese Red Cross Medical Center

抄録

Changes in the lymphocyte subsets of 13 patients with varicella, 5 with hand-foot-and-mouth disease, 4 with scarlet fever, 10 with measles and 20 with Kawasaki disease were examined by immunofluorescent flow cytometric analysis using monoclonal antibodies against lymphocyte cell surface antigens. The results were compared with those of age-matched normal controls. A significant increase in the percentage of Leu-2a positive (Leu-2a+) cells was shown during the early convalescence of varicella, scarlet fever and measles. A significant decrease in the percentage of Leu-3a+ cells during the acute phase was common to all the diseases examined, and a significant decrease of Leu-4+ cells was observed except in measles. As a result, a significant decrease in the Leu-3a+/Leu-2a+ ratio was common to all the diseases examined during the acute and/or early convalescent phases. Leu-M3+ cells increased significantly in varicella, scarlet fever, and Kawasaki disease. HLA-DR+ cells increased significantly in varicella and Kawasaki disease. No significant changes in the proportions of Leu-7+, Leu-10+, and 2H7+ cells were found throughout the course of all the diseases examined.

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