Variation of Virulence and Other Properties among Sendai Virus Strains

J-STAGE
  • YAMAGUCHI Ryoji
    Department of Veterinary Public Health, The Institute of Public Health
  • IWAI Hiroshi
    Department of Veterinary Public Health, The Institute of Public Health
  • UEDA Katsumoto
    Department of Veterinary Public Health, The Institute of Public Health

Abstract

The virulence of five Sendai virus strains (MN, Z, KN, Mol, and Hm) isolated from laboratory rodents was compared, using 3-week-old female Jcl-ICR mice. The virulence of the strains was Mol, MN, KN, Z, and Hm in decreasing order. The 50% lethal dose and 50% lung consolidation inducing dose of the highest virulent strain differed by the order of more than 103 and 106, respectively, from those of the lowest virulent one. Other properties such as the growth rate in LLC-MK2 cells, neuraminidase activities, and molecular weights of structural proteins also differed among the virus strains. These results indicate that Sendai virus prevailing in laboratory rodents is not homogenous with respect to virulence and some other properties.

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