Monoclonal Antibody to a Structure Expressed on a Subpopulation of Rat CD8 T Cell Subsets
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- NAGOYA Satoshi
- Department of Pathology, Sapporo Medical College
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- KIKUCHI Kokichi
- Department of Pathology, Sapporo Medical College
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- UEDE Toshimitsu
- Section of Immunopathogenesis, Institute of Immunological Science, Hokkaido University
抄録
We have developed a monoclonal antibody, RTS-1, which can divide a rat CD8 (+) peripheral T cell population into two functionally distinct subsets. The cell-surface structure defined by this antibody is a glycoprotein with a molecular weight of 220kDa found to be a high molecular isoform of rat CD45 antigen. CD4 (+) T cells were not stained by RTS-1 antibody. The cytotoxic T cell-enriched population did not express RTS-1 epitope on the cell surface. CD8 (+) spleen cells as well as RTS-1(+)CD8(+)T cells exhibited strong inhibition on mitogen-induced immunoglobulin G production by rat B cells. Furthermore, RTS-1 antibody, but not the control antibody, abolished CD8(+)T cell-mediated inhibition of immunoglobulin G production by rat B cells. These data suggest that RTS-1 antibody recognizes a unique determinant of rat CD45 antigen that is expressed on a fraction of CD8(+) cells.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 35 (10), 895-911, 1991
Center For Academic Publications Japan
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詳細情報 詳細情報について
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- CRID
- 1571135653080996352
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- NII論文ID
- 130003483720
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles